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Accelerated Technologies Center for Gene to 3D Structure

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 ATCG3D Mission

The Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) is an NIH Protein Structure Initiative Specialized Center focused on the accelerated development, integration, and deployment of three emerging technologies (tunable laboratory X-ray source, synthetic gene design, and nanovolume microfluidic crystallization) which have high potential to improve the economics of protein structure determination by X-ray crystallographic methods.

The ATCG3D is a specialized center of the Protein Structure Initiative Research Network (http://www.nigms.nih.gov/psi) and is funded by the NIH NIGMS and NIH NCRR.

 Research Opportunities and Open Positions

 ATCG3D News
Novel CrystalCardsTM Produce 3D Protein Structures from Nanovolume SamplesUse SHIFT+ENTER to open the menu (new window).
11/16/2008
Use of Cyclodextrins for Crystallization of Membrane ProteinsUse SHIFT+ENTER to open the menu (new window).
11/16/2008
Protein Linked to Spinal Muscular Atrophy IdentifiedUse SHIFT+ENTER to open the menu (new window).
11/16/2008
Microcapillary Protein Crystallization Workshop - June 6-7Use SHIFT+ENTER to open the menu (new window).
2/12/2008
Plastic Micro-Channel Platform for Counter-Diffusion Crystallography Use SHIFT+ENTER to open the menu (new window).
10/26/2007
Gene Composer™ Software for Synthetic Gene Design and Construct EngineeringUse SHIFT+ENTER to open the menu (new window).
8/1/2007
Nanovolume Plug-Based Microfluidic Crystallization Labcards and SystemUse SHIFT+ENTER to open the menu (new window).
8/1/2007
Microfluidic Hybrid Method for Protein CrystallizationUse SHIFT+ENTER to open the menu (new window).
8/1/2007
DETECT-X Crystal Imaging TechnologyUse SHIFT+ENTER to open the menu (new window).
8/1/2007
Miniature Synchrotron Sheds New Light on Research, RSNAUse SHIFT+ENTER to open the menu (new window).
6/1/2006
"Accelerated Technologies Center for Gene to 3D Structure" funded by the National Institute of Health, Institute of General Medical Sciences' Protein Structure Initiative and the National Center for Research ResourcesUse SHIFT+ENTER to open the menu (new window).
6/24/2005
Automating, Miniturizing X-ray Crystallography, Drug Discovery & DevelopmentUse SHIFT+ENTER to open the menu (new window).
3/2/2005
First complete data set collected using in-situ x-ray diffraction on capillary grown crystals at GM/CA CAT. Use SHIFT+ENTER to open the menu (new window).
3/1/2005
First in-situ x-ray diffraction experiments from capillary based microfluidics experiments at APS GM/CA CAT beamline completed in Dec 2004Use SHIFT+ENTER to open the menu (new window).
12/1/2004

 ATCG3D Publications
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.Use SHIFT+ENTER to open the menu (new window).New
Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC ScienceScience Magazine11/21/2008
The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).Use SHIFT+ENTER to open the menu (new window).New
Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli AJ, Staker BL, Nollert P, Stewart LActa Crystallographica Section D: Biological CrystallographyPubMed Central10/18/2008
DcpS as a therapeutic target for spinal muscular atrophy.Use SHIFT+ENTER to open the menu (new window).New
Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney MEACS Chemical BiologyAmerican Chemical Society Publications10/8/2008
  		 

 PSI Structural Genomics KB - Updates
Retrieving Data

 PSI Structural Genomics KB - New Molecules
Retrieving Data

 This Week in Pictures

 Member Laboratories
NotesFilter
Peter Kuhn and Ray Stevens labs at TSRI
The Kuhn and Stevens labs focus on understanding viruses and their host interactions through protein structure determination on a proteome-wide scale using advanced high-throughput structural genomics technologies, with a view to developing novel therapeutics and diagnostics.
Decode Biostructures and Lance Stewart
deCODE biostructures, located in Bainbridge Island, WA, is a leading provider of contract research services with capabilities that span the entire gene-to-structure landscape including gene synthesis, gene construct engineering, large-scale protein production and purification, high-throughput crystallization screening, pre-formulation screening of small molecules, X-ray diffraction data collection, model building, and refinement.
Lyncean Technologies, Inc.
Lyncean Technologies, Inc., located in Palo Alto, CA, has developed a new generation of compact X-ray sources - miniature synchrotron light sources. These powerful home-lab-size X-ray sources will enable scientists in academics and industry to pursue state-of-the-art synchrotron radiation applications in their own laboratories.
Ismagilov Group at the University of Chicago
The research goal of the Ismagilov Lab is to understand chemical and biological complexity, both top down at the level of systems and bottom up at the level of molecular components. Using chemistry, biological systems respond and adapt to their environments, perform fascinating functions, and even think.

 Links
  Viral Infection Structural Proteomics
  Cancer
  SARS Coronavirus
  PKU Therapeutics
  PPI: Understanding and Modulating Protein-Protein Interaction
  New Technologies in Structural Biology
  JCIMPT: JCSG Center for Innovative Membrane Protein Technologies
  C-ME: Collaborative Molecular Modeling Environment
  Stevens Lab
  Scripps-PARC Institute for Advanced Biomedical Sciences
  Kuhn Lab Portal
  Gene Composer TM Software Downloads