ATCG3D News - Gene Composer™ Software for Synthetic Gene...

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Gene Composer™ Software for Synthetic Gene Design and Construct Engineering

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Description: Gene Composer™ Express and Gene Composer™ Lite software for computer aided construct engineering and expression optimized synthetic gene design are available for download from www.genecomposer.net/download. Gene Composer™ Express is a complete synthetic gene design suite for Microsoft Windows® which runs on top of a single user Access® database with an Alignment Viewer, Construct Design Module, and Gene Design Module. The Express software has recently been upgraded with features that allow virtual cloning of designed constructs into expression vectors by way of user defined adaptor assemblies that recapitulate most wet lab cloning procedures.

Gene Composer™ Lite is a Java™-based Protein-to-DNA algorithm that allows users to design codon optimized DNA sequences based on the original cDNA or amino acid sequence data. Both the Express and Lite versions of the software allow the design of synthetic genes with all "ACA" sequences silently removed from open reading frames, so that they may be used in conjunction with the MazF system for single protein production.

Once every ~2 months deCODE biostructures hosts a 2 hour on-line ATCG3D workshop on the use of Gene Composer™ software for expression optimized synthetic gene design and protocols for PCR-based gene synthesis from designed oligonucleotides and improved error reduction through the use of mis-match specific endonucleases. Workshops are typically been held on the first Friday of every other month, (June 1, August 3 etc.). Registration and video recordings of workshops are located at www.genecomposer.net/workshop.

Contact: Lance Stewart, lstewart@decode.com

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http://www.genecomposer.net

Keyword

Gene Composer

Date

8/1/2007

Authors

Lance Stewart

Attachments

Accelerated Technologies Center for Gene to 3D Structure