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Accelerated Technologies Center for Gene to 3D Structure > ATCG3D Publications  

ATCG3D Publications

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Hard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-raysUse SHIFT+ENTER to open the menu (new window).
Bech M, Bunk O, David C, Ruth R, Rifkin J, Loewen R, Feidenhans'l R, Pfeiffer FJournal of Synchrotron RadiationIUCr Crystallography Journals11/27/2008
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.Use SHIFT+ENTER to open the menu (new window).
Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC ScienceScience Magazine11/21/2008
The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).Use SHIFT+ENTER to open the menu (new window).
Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli AJ, Staker BL, Nollert P, Stewart LActa Crystallographica Section D: Biological CrystallographyPubMed Central10/18/2008
DcpS as a therapeutic target for spinal muscular atrophy.Use SHIFT+ENTER to open the menu (new window).
Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney MEACS Chemical BiologyAmerican Chemical Society Publications10/8/2008
Simple host-guest chemistry to modulate the process of concentration and crystallization of membrane proteins by detergent capture in a microfluidic device.Use SHIFT+ENTER to open the menu (new window).
Li L, Nachtergaele S, Seddon AM, Tereshko V, Ponomarenko N, Ismagilov RFJournal of the American Chemical SocietyAmerican Chemical Society Publications10/3/2008
A specific cholesterol binding site is established by the 2.8 Å structure of the human beta2-adrenergic receptor.Use SHIFT+ENTER to open the menu (new window).
Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EY, Velasquez J, Kuhn P, Stevens RC StructureElsevier Article Locator6/10/2008
Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics Use SHIFT+ENTER to open the menu (new window).
Ng JD, Stevens RC, Kuhn PMethods in Molecular Biology  SpringerLink6/10/2008
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.Use SHIFT+ENTER to open the menu (new window).
Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, Bokoch GM, Tainer JA, Weckbecker G, Kuhn PJournal of Molecular BiologyScience Direct5/17/2008
C-ME: a 3D community-based, real-time collaboration tool for scientific research and training.Use SHIFT+ENTER to open the menu (new window).
Kolatkar A, Kennedy K, Halabuk D, Kunken J, Marrinucci D, Bethel K, Guzman R, Huckaby T, Kuhn PPLoS ONEPubMed Central2/20/2008
In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels.Use SHIFT+ENTER to open the menu (new window).
Ng JD, Clark PJ, Stevens RC, Kuhn PActa Crystallographica Section D: Biological CrystallographyIUCr Online1/16/2008
Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.Use SHIFT+ENTER to open the menu (new window).
Chrencik JE, Brooun A, Recht MI, Nicola G, Davis LK, Abagyan R, Widmer H, Pasquale EB, Kuhn PJournal of Biological ChemistryJournal of Biological Chemistry12/14/2007
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.Use SHIFT+ENTER to open the menu (new window).
Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BKScienceScience Magazine10/25/2007
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.Use SHIFT+ENTER to open the menu (new window).
Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RCScienceScience Magazine10/25/2007
Gene Synthesis for Protein ProductionUse SHIFT+ENTER to open the menu (new window).
Stewart LEncyclopedia of Life SciencesWiley InterScience9/28/2007
Using three-phase flow of immiscible liquids to prevent coalescence of droplets in microfluidic channels: criteria to identify the third liquid and validation with protein crystallization.Use SHIFT+ENTER to open the menu (new window).
Chen DL, Li L, Reyes S, Adamson DN, Ismagilov RFLangmuirACS Publications1/4/2007
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteinsUse SHIFT+ENTER to open the menu (new window).
Liang Li, Debarshi Mustafi, Qiang Fu, Valentina Tereshko, Delai L. Chen, Joshua D. Tice, and Rustem F. Ismagilov PNASPubMed Entry12/12/2006ATCG3D
Time-Controlled Microfluidic Seeding in nL-Volume Droplets to Separate Nucleation and Growth Stages of Protein CrystallizationUse SHIFT+ENTER to open the menu (new window).
Gerdts CJ, et al    Angewandte Chemie Int. Ed Engl.  DOI:10.1038/nature0541112/11/2006ATCG3D 
Remedial strategies in structural proteomics: Expression, purification, and crystallization of the Vav1/Rac1 complexUse SHIFT+ENTER to open the menu (new window).
Brooun A, Foster SA, Chrencik JE, Chien EYT, Kolatkar AR, Streiff M, Ramage P, Widmer H, Weckbecker G, Kuhn PProtein Expression and PurificationScience Direct12/5/2006ATCG3D
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins.Use SHIFT+ENTER to open the menu (new window).
Li L, Mustafi D, Fu Q, Tereshko V, Chen DL, Tice JD, Ismagilov RFProceedings of the National Academy of Sciences of the United States of AmericaPNAS Online10/27/2006
Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices.Use SHIFT+ENTER to open the menu (new window).
Adamson DN, Mustafi D, Zhang JX, Zheng B, Ismagilov RFLab on a ChipPubMed Central7/27/2006
Microfluidic cartridges preloaded with nanoliter plugs of reagents: an alternative to 96-well plates for screening.Use SHIFT+ENTER to open the menu (new window).
Chen DL, Ismagilov RF Current Opinion in Chemical BiologyScience Direct5/3/2006
In situ data collection and structure refinement from microcapillary protein crystallizationUse SHIFT+ENTER to open the menu (new window).
Yadav M.K., et al.  Journal Applied Crystallography  Applied Crystallography Online12/14/2005ATCG3D
In situ data collection and structure refinement from microcapillary protein crystallization.Use SHIFT+ENTER to open the menu (new window).
Yadav MK, Gerdts CJ, Sanishvili R, Smith WW, Roach LS, Ismagilov RF, Kuhn P, Stevens RCJournal of Applied CrystallographyPubMed Central11/12/2005
Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization.Use SHIFT+ENTER to open the menu (new window).
Zheng B, Gerdts CJ, Ismagilov RFCurrent Opinion in Structural BiologyScience Direct9/8/2005
Reduction in diffuse-convective disturbances in nanovolume protein crystallization experimentsUse SHIFT+ENTER to open the menu (new window).
D.C. Carter, P. Rhodes, D.E. McRee, L. Tari, D.R. Dougan, G. Snell, E. Abola, R.C. StevensJ. Appl. CrystLink5/1/2005
Shotgun Crystallization Strategy for Structural Genomics II: Crystals and Conditions that Produce High Resolution Structures for T. maritima ProteinsUse SHIFT+ENTER to open the menu (new window).
R. Page, S. Lesley, A. Deacon, R. C. StevensJ. Funct. Struct. GenomicsPubMed Entry4/1/2005
NMR Screening of Mouse Homolog Proteins in a Structural Proteomics PipelineUse SHIFT+ENTER to open the menu (new window).
R. Page, W. Peti, K. Moy, I. Wilson, R. Stevens, K. WuthrichProc. Natl. Acad. Sci. USALink3/1/2005
Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I-DNA Covalent ComplexUse SHIFT+ENTER to open the menu (new window).
B. L. Staker, M. D. Feese, M. Cushman, Y. Pommier, D. Zembower, L. Stewart, and A. B. Burgin J. Med. Chem.PubMed Entry2/1/2005
Whole Gene Synthesis: A Gene-O-Matic Future. Use SHIFT+ENTER to open the menu (new window).
L. Stewart and Alex B. Burgin In  Frontiers in Drug Design and Discovery. Bentham Science Publishers, Ltd,1/1/2005
Automatic classification of protein crystallization images using a curve tracking algorithmUse SHIFT+ENTER to open the menu (new window).
M. Bern, D. Goldberg, R.C. Stevens, P. KuhnJ. Appl. Cryst.Link8/1/2004
Protein biophysical properties that correlate with crystallization success in Thermotoga Maritima: Maximum clustering strategy for structural genomicsUse SHIFT+ENTER to open the menu (new window).
J.M. Canaves, R. Page, R.C. StevensJ. Molec. BiolPubMed Entry8/1/2004
Mechanisms of camptothecin resistance by human topoisomerase I mutationsUse SHIFT+ENTER to open the menu (new window).
Chrencik, J. E., B. L. Staker, A. B. Burgin, P. Pourquier, Y. Pommier, L. Stewart, M. R. RedinboJ. Mol. Biol.PubMed Entry7/1/2004
Protein structure prediction and analysis using the Robetta serverUse SHIFT+ENTER to open the menu (new window).
D.E. Kim, D. Chivian, D. BakerNucleic Acids Res.PubMed Entry7/1/2004
Climbing Mount Everest, the GPCR wayUse SHIFT+ENTER to open the menu (new window).
Nollert, P. and L. Stewart.Drug Discovery Today6/1/2004
Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screensUse SHIFT+ENTER to open the menu (new window).
R. Page, R.C. StevensMethodsPubMed Entry5/1/2004
Improvement of Comparative Model Accuracy by Free Energy Optimization along Principal Components of Natural Structural VariationUse SHIFT+ENTER to open the menu (new window).
B. Qian, A. Ortiz, D. Baker.Proc. Natl. Acad. Sci. U.S.A.PubMed Entry4/19/2004
Raid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MSUse SHIFT+ENTER to open the menu (new window).
D. Pantazatos, J.S. Kim, H.E. Klock, R.C. Stevens, I.A. Wilson, S.A. Lesley, V.L. Woods JrProc. Natl. Acad. Aci U.S.A.Link4/1/2004
Scalable high-throughput micro-expression device for recombinant proteinsUse SHIFT+ENTER to open the menu (new window).
R. Page, K. Moy, E.C. Sims, J. Velasquez, B. McManus, C. Grittini, T.L. Clayton, R.C. StevensBioTechniquesPubMed Entry4/1/2004
Automated sample mounting and alignment system for biological crystallography at a synchrotron sourceUse SHIFT+ENTER to open the menu (new window).
G. Snell, C. Cork, R. Nordmeyer, E. Cornell, G. Meigs, D. Yegian, J. Jaklevic, J. Jin, R.C. Stevens, T. Earnest StructurePubMed Entry3/1/2004
Alternative splicing of mouse transcription factors affects their DNA-binding domain architecture and is tissue specificUse SHIFT+ENTER to open the menu (new window).
B. Taneri, B. Snyder, A. Novoradovsky, T. Gaasterland.Genome Biol.PubMed Entry2/1/2004
Long Live Structural BiologyUse SHIFT+ENTER to open the menu (new window).
R.C. StevensNature Struct. Molec. Biol.PubMed Entry2/1/2004
A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip x-ray diffractionUse SHIFT+ENTER to open the menu (new window).
B. Zheng, J.D. Tice, L.S. Roach, R.F. IsmagilovAngew. Chem. Int. Edit.PubMed Entry1/1/2004
A Fully Integrated Protein Crystallization Platform for Small Molecule Drug DiscoveryUse SHIFT+ENTER to open the menu (new window).
D. Hosfield, J. Palan, M. Hilgers, D. Scheibe, D. McRee, R.C. StevensJ. Struct. Biol.PubMed Entry5/1/2003
Shotgun crystallization strategy for structural genomics: An optimized two-tiered crystallization screen against the Thermatoga maritima proteomeUse SHIFT+ENTER to open the menu (new window).
R. Page, S.K. Grzechnik, J. Canaves, G. Spraggon, A. Kreusch, R.C. Stevens, S. Lesley.Acta Crystallogr. DPubMed Entry4/1/2003
The cost and value of three-dimensional protein structureUse SHIFT+ENTER to open the menu (new window).
R.C. StevensDrug Discovery Worldhttp://atcg3d.org/PDF/Stevens_DDW2003.pdf3/1/2003
Robotics for Automated Crystal Formation and AnalysisUse SHIFT+ENTER to open the menu (new window).
M. Weselak, M.G. Patch, T.L. Selby, G. Knebel, R.C. StevensMethods in Enzymology. Eds. C.W. Carter & R.M. Sweet. Academic Press: San Diego CAPubMed Entry2/1/2003
Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size dropletsUse SHIFT+ENTER to open the menu (new window).
B. Zheng, L.S. Roach, R.F. Ismagilov.J. Am. Chem. Soc.PubMed Entry1/1/2003
The genesis of high-throughput structure-based drug discovery using protein crystallographyUse SHIFT+ENTER to open the menu (new window).
P. Kuhn, K. Wilson, M.G. Patch, R.C. Stevens Curr. Opin. Chem. Biol.PubMed Entry5/1/2002
Blu-Ice and the distributed control system: software for data acquisition and instrument control at macromolecular crystallography beamlinesUse SHIFT+ENTER to open the menu (new window).
T.M. McPhillips, S.E. McPhillips, H.J. Chiu, A.E. Cohen, A.M. Deacon, P.J. Ellis, E. Garman, A. Gonzalez, N.K. Sauter, R.P. Phizackerley, S.M. Soltis, P. Kuhn. J. Synchrotron Radiat.PubMed Entry4/1/2002
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipelineUse SHIFT+ENTER to open the menu (new window).
S.A. Lesley, P. Kuhn, A. Godzik, A.M. Deacon, I. Mathews, A. Kreusch, G. Spraggon, H.E. Klock, D. McMullan, T. Shin, J. Vincent, A. Robb, L.S. Brinen, M.D. Miller, T.M. McPhillips, M.A. Miller, D. Scheibe, J.M. Canaves, C. Guda, L. Jaroszewski, T.L. SelbyProc. Natl. Acad. Sci. USAPubMed Entry4/1/2002
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