Skip to main content

Accelerated Technologies Center for Gene to 3D Structure

Go Search
Home
About
Background
Biomedical Applications
Technologies
Targets
Contact Us
  
Accelerated Technologies Center for Gene to 3D Structure > Pages > about  

 

 

About the Accelerated Technologies Center for Gene to 3D structure.

Mission:

The work of the Accelerated Technologies Center for Gene to 3D Structure is focused on the development, operation and deployment of novel approaches in miniaturization, integration and automation with an aim towards lowering the overall cost of gene to structure for all researchers.

Primary initiatives include

  • whole gene synthesis for the production of optimized protein constructs and

  • parallel protein purification with integrated small-scale biophysical characterization from deCODE biostructures,

  • micro-capillary based crystallization technologies from the University of Chicago

  • the tunable Compact X-ray Light Source from Lyncean Technologies, Inc..

Fully developed instruments and refined methods will be deployed into the Center’s laboratory at The Scripps Research Institute for final integration, testing and operation. The initial target application area is oncology, specifically focusing on eukaryotic protein families and more challenging proteins such as multi-protein kinase complexes, DNA-bound transcription factors, and integral membrane proteins.  The established technologies will be commercially available to the scientific community through Emerald BioSystems (a subsidiary of deCODE biostructures), Lyncean Technologies, and Micronics.

________________________________________________________________Top of the page

About:

About deCODE biostructures

deCODE biostructures, located in Bainbridge Island, WA, is a leading provider of contract research services with capabilities that span the entire gene-to-structure landscape including gene synthesis, gene construct engineering, large-scale protein production and purification, high-throughput crystallization screening, pre-formulation screening of small molecules, X-ray diffraction data collection, model building, and refinement. The work of deCODE biostructures can be integrated with the services of sister company, deCODE chemistry, a leading provider of contract research services in pharmaceutical discovery and development based in Woodridge, Illinois. Together, these groups can offer to clients a structure-based approach to drug design with a full range of contract services all the way through the manufacture of compounds for clinical trials. deCODE biostructures and deCODE chemistry are wholly-owned subsidiaries of deCODE genetics, Inc., a biopharmaceutical company headquartered in Reykjavik, Iceland.

 

Emerald BioSystems, a subsidiary of deCODE biostructures, was launched in January 2005 to commercialize a complete line of liquid-handling robotics, software and consumable products discovered and developed through the work of deCODE biostructures in its goal to eliminate bottlenecks in the gene-to-structure path. Emerald BioSystems also operates from Bainbridge Island, WA.

 About The Scripps Research Institute and Scripps Florida

The Scripps Research Institute in La Jolla, California, and Palm Beach County, Florida, is one of the world's largest, independent, non-profit biomedical research organizations.  It stands at the forefront of basic biomedical science that seeks to comprehend the most fundamental processes of life. Scripps Research is internationally recognized for its research into immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune, cardiovascular, and infectious diseases, and synthetic vaccine development.

The Scripps Research Institute employs approximately 3,000 scientists, postdoctoral fellows, scientific and other technicians, doctoral degree graduate students, and administrative and technical support personnel in 14 buildings overlooking the Pacific Ocean in La Jolla, a part of the City of San Diego.

Scripps Florida will be a 350,000 square-foot, state-of-the-art biomedical research facility to be built on 100 acres of undeveloped land in Palm Beach County. Scripps Florida will focus on basic biomedical science, drug discovery, and technology development, employing more than 500 researchers and support staff by 2010. Palm Beach County and the State of Florida have provided start-up economic incentives for development, building, staffing, and equipping the campus.

Scripps Florida is now operating with more than 100 researchers and technicians at a 40,000 square-foot facility on the campus of Florida Atlantic University in Jupiter.

 About Lyncean Technologies, Inc.

Lyncean Technologies, Inc., located in Palo Alto, CA, has developed a new generation of compact X-ray sources - miniature synchrotron light sources. These powerful home-lab-size X-ray sources will enable scientists in academics and industry to pursue state-of-the-art synchrotron radiation applications in their own laboratories. Lyncean's first product, the Compact Light Source, is optimized for protein crystallography and will deliver monochromatic pencil beams of tunable hard X-rays comparable in quality and flux to some of the most productive synchrotron beamlines in use today.

About micronics

Based in Redmond, Washington, Micronics is a leading provider of laboratory-on-a-card (“lab card”) design, development and production services on behalf of clients worldwide. Micronics' patented microfluidics and microplumbing technologies, coupled with its expertise in integrating protein crystallography, molecular and immunoassays on-card, allow it to fundamentally modify the way in which fluids are processed and assays are performed at greatly reduced volumes, time and cost. Micronics uniquely integrates other components into its lab cards as well, such as printed reagents, membranes, sensors, valves and electrodes. Micronics is believed to offer the most sophisticated and rapid lab card prototyping facility in the world today. For additional information, see www.micronics.net.

About the University of Chicago

The University of Chicago is a private, nondenominational, coeducational institution of higher learning and research. It is located in the community of Hyde Park-South Kenwood, a culturally rich and ethnically diverse neighborhood seven miles south of downtown Chicago. Hyde Park and South Kenwood encompass one and one-quarter square miles of commercial and residential districts that extend from 47th Street on the north to 61st Street on the south and from Cottage Grove Avenue eastward to the shoreline of Lake Michigan. The neighborhood is a stimulating blend of the urban and small town.