About the Accelerated Technologies Center for Gene to 3D Structure
Description:
The work of the Accelerated Technologies Center for Gene to 3D Structure is focused on the development and dissemination of three emerging technologies which are expected to improve the economics of protein structure determination by X-ray crystallographic methods.
Primary technology development initiatives include:
· Computer-aided synthetic gene design and protein construct engineering (Gene Composer)
· Nanovolume microcapillary crystallization methods and devices (CrystalCards and CrystalSlides)
· A Tunable laboratory X-ray source (Compact Light Source)
The technologies are being made commercially available to the scientific community through Emerald BioStructures, Greiner BioOne, Lyncean Technologies, and other qualified corporate partners.
The fully developed ATCG3D technologies, together with other reported membrane protein technology breakthroughs, are being applied by ATCG3D researchers towards the structure determination of human G-Protein Coupled Receptors (GPCRs). The GPCR target processing effort is directed at providing a much better understanding of structural plasticity in this superfamily of medically relevant integral membrane proteins.
ATCG3D Participating Institutions:
Emerald BioStructures (http://www.emeraldbiostructures.com)
The Scripps Research Institute (http://kuhn.scripps.edu/default.aspx)
University of Chicago (http://ismagilovlab.uchicago.edu)
Lyncean Technologies, Inc. (http://www.lynceantech.com/)
ATCG3D Investigators:
Lance Stewart, Emerald BioStructures (PI)
Peter Kuhn, The Scripps Research Institution (Co-PI)
Raymond Stevens, The Scripps Research Institution (Co-PI)
Rustem Ismagilov, The University of Chicago (Participating PI)
Ronald Ruth, Lyncean Technologies, Inc. (Participating PI)
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About:
About Emerald biostructures
One of the largest gene-to-structure contract research organizations in the US, Emerald BioStructures has 12 years of experience providing collaborative drug discovery research services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. Emerald BioStructures operates a high throughput platform that is leveraged for fragment based lead discovery and structure based drug design through numerous collaborations including the Seattle Structural Genomics Center for Infectious Disease (www.SSGCID.org) and the Accelerated Technologies Center for Gene to 3D Structure (www.ATCG3D.org).
http://www.emeraldbiostructures.com/
Emerald BioSystems is a leading provider of sophisticated laboratory automation, bioinformatics software, reagent kits and plastic-ware products to structural biologists. Emerald’s research tools accelerate the gene-to-protein-structure determination process through advanced computer aided gene design, automated cell-free protein expression, protein purification, and crystallization. A high level of efficiency for protein crystal generation can be achieved using Emerald’s novel Microcapillary Protein Crystallization System (MPCS™) Plug Maker™ and CrystalCards™ for nanovolume microfluidic crystallization.
http://www.emeraldbiosystems.com/
About The Scripps Research Institute and Scripps Florida
The Scripps Research Institute in La Jolla, California, and Palm Beach County, Florida, is one of the world's largest, independent, non-profit biomedical research organizations. It stands at the forefront of basic biomedical science that seeks to comprehend the most fundamental processes of life. Scripps Research is internationally recognized for its research into immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune, cardiovascular, and infectious diseases, and synthetic vaccine development.
The Scripps Research Institute employs approximately 3,000 scientists, postdoctoral fellows, scientific and other technicians, doctoral degree graduate students, and administrative and technical support personnel in 14 buildings overlooking the Pacific Ocean in La Jolla, a part of the City of San Diego.
Scripps Florida will be a 350,000 square-foot, state-of-the-art biomedical research facility to be built on 100 acres of undeveloped land in Palm Beach County. Scripps Florida will focus on basic biomedical science, drug discovery, and technology development, employing more than 500 researchers and support staff by 2010. Palm Beach County and the State of Florida have provided start-up economic incentives for development, building, staffing, and equipping the campus.
Scripps Florida is now operating with more than 100 researchers and technicians at a 40,000 square-foot facility on the campus of Florida Atlantic University in Jupiter.
About Lyncean Technologies, Inc.
Lyncean Technologies, Inc., located in Palo Alto, CA, has developed a new generation of compact X-ray sources - miniature synchrotron light sources. These powerful home-lab-size X-ray sources will enable scientists in academics and industry to pursue state-of-the-art synchrotron radiation applications in their own laboratories. Lyncean's first product, the Compact Light Source, is optimized for protein crystallography and will deliver monochromatic pencil beams of tunable hard X-rays comparable in quality and flux to some of the most productive synchrotron beamlines in use today.
About the University of Chicago
The University of Chicago is a private, nondenominational, coeducational institution of higher learning and research. It is located in the community of Hyde Park-South Kenwood, a culturally rich and ethnically diverse neighborhood seven miles south of downtown Chicago. Hyde Park and South Kenwood encompass one and one-quarter square miles of commercial and residential districts that extend from 47th Street on the north to 61st Street on the south and from Cottage Grove Avenue eastward to the shoreline of Lake Michigan. The neighborhood is a stimulating blend of the urban and small town.