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Accelerated Technologies Center for Gene to 3D Structure

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 ATCG3D Mission

The 2010 NIGMS Workshop: Enabling Technologies in Structure and Function continues a series of annual meetings held by NIGMS Protein Structure Initiative participants, which were popularly designated "Bottlenecks" Workshops. The primary focus of this 2½ day meeting will be the technical issues affecting the speed, cost, and success of protein structure determination and the combination of structure with other biophysical methods to enable functional characterization of macromolecules.

Click the following link to download the flyer: Flyer

 http://meetings.nigms.nih.gov/index.cfm?event=general&ID=8126

The Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) is an NIH Protein Structure Initiative Specialized Center focused on the accelerated development, integration, and deployment of three emerging technologies (tunable laboratory X-ray source, synthetic gene design, and nanovolume microfluidic crystallization) which have high potential to improve the economics of protein structure determination by X-ray crystallographic methods.

The ATCG3D is a specialized center of the Protein Structure Initiative Research Network (http://www.nigms.nih.gov/psi) and is funded by the NIH NIGMS and NIH NCRR.

 Research Opportunities and Open Positions

 ATCG3D News

Emerald BioSystems Plug Maker™ wins ALA 2010 New Product AwardUse SHIFT+ENTER to open the menu (new window).
1/26/2010
2010 NIGMS Enabling Technologies Meeting, April 19-21, 2010Use SHIFT+ENTER to open the menu (new window).
12/15/2009
Emerald Companies acquired by Beryllium, LLC. Now independent of deCODE genetics, Inc.Use SHIFT+ENTER to open the menu (new window).
11/13/2009
Hard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-raysUse SHIFT+ENTER to open the menu (new window).
1/24/2009
MPCS User Facility Opens in Woodridge, ILUse SHIFT+ENTER to open the menu (new window).
12/4/2008
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonistUse SHIFT+ENTER to open the menu (new window).
11/21/2008
Novel CrystalCardsTM Produce 3D Protein Structures from Nanovolume SamplesUse SHIFT+ENTER to open the menu (new window).
11/16/2008
Use of Cyclodextrins for Crystallization of Membrane ProteinsUse SHIFT+ENTER to open the menu (new window).
11/16/2008
Protein Linked to Spinal Muscular Atrophy IdentifiedUse SHIFT+ENTER to open the menu (new window).
11/16/2008
Microcapillary Protein Crystallization Workshop - June 6-7Use SHIFT+ENTER to open the menu (new window).
2/12/2008
Plastic Micro-Channel Platform for Counter-Diffusion Crystallography Use SHIFT+ENTER to open the menu (new window).
10/26/2007
Gene Composer™ Software for Synthetic Gene Design and Construct EngineeringUse SHIFT+ENTER to open the menu (new window).
8/1/2007
Nanovolume Plug-Based Microfluidic Crystallization Labcards and SystemUse SHIFT+ENTER to open the menu (new window).
8/1/2007
Microfluidic Hybrid Method for Protein CrystallizationUse SHIFT+ENTER to open the menu (new window).
8/1/2007
DETECT-X Crystal Imaging TechnologyUse SHIFT+ENTER to open the menu (new window).
8/1/2007
Miniature Synchrotron Sheds New Light on Research, RSNAUse SHIFT+ENTER to open the menu (new window).
6/1/2006
"Accelerated Technologies Center for Gene to 3D Structure" funded by the National Institute of Health, Institute of General Medical Sciences' Protein Structure Initiative and the National Center for Research ResourcesUse SHIFT+ENTER to open the menu (new window).
6/24/2005
Automating, Miniturizing X-ray Crystallography, Drug Discovery & DevelopmentUse SHIFT+ENTER to open the menu (new window).
3/2/2005
First complete data set collected using in-situ x-ray diffraction on capillary grown crystals at GM/CA CAT. Use SHIFT+ENTER to open the menu (new window).
3/1/2005
First in-situ x-ray diffraction experiments from capillary based microfluidics experiments at APS GM/CA CAT beamline completed in Dec 2004Use SHIFT+ENTER to open the menu (new window).
12/1/2004

 ATCG3D Publications

Hard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-raysUse SHIFT+ENTER to open the menu (new window).
Bech M, Bunk O, David C, Ruth R, Rifkin J, Loewen R, Feidenhans'l R, Pfeiffer FJournal of Synchrotron RadiationIUCr Crystallography Journals11/27/2008
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.Use SHIFT+ENTER to open the menu (new window).
Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC ScienceScience Magazine11/21/2008
The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).Use SHIFT+ENTER to open the menu (new window).
Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli AJ, Staker BL, Nollert P, Stewart LActa Crystallographica Section D: Biological CrystallographyPubMed Central10/18/2008
 
 

 PSI Structural Genomics KB - Updates

Retrieving Data

 PSI Structural Genomics KB - New Molecules

Retrieving Data

 This Week in Pictures

Tuesday, January 20, 2009
ATCG3D_Overview.jpg
ATCG3D Overview
  View slide show

 Member Laboratories

NotesFilter
Peter Kuhn and Ray Stevens labs at TSRI
The Kuhn and Stevens labs focus on understanding viruses and their host interactions through protein structure determination on a proteome-wide scale using advanced high-throughput structural genomics technologies, with a view to developing novel therapeutics and diagnostics.
Emerald Biostructures and Lance Stewart
One of the largest gene-to-structure contract research organizations in the US,  Emerald BioStructures has 12 years of experience providing collaborative drug discovery research services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities.   Emerald BioStructures operates a high throughput platform that is leveraged for fragment based lead discovery and structure based drug design through numerous collaborations including the Seattle Structural Genomics Center for Infectious Disease (www.SSGCID.org) and the Accelerated Technologies Center for Gene to 3D Structure (www.ATCG3D.org).
Lyncean Technologies, Inc.
Lyncean Technologies, Inc., located in Palo Alto, CA, has developed a new generation of compact X-ray sources - miniature synchrotron light sources. These powerful home-lab-size X-ray sources will enable scientists in academics and industry to pursue state-of-the-art synchrotron radiation applications in their own laboratories.
Ismagilov Group at the University of Chicago
The research goal of the Ismagilov Lab is to understand chemical and biological complexity, both top down at the level of systems and bottom up at the level of molecular components. Using chemistry, biological systems respond and adapt to their environments, perform fascinating functions, and even think.

 Links

  Viral Infection Structural Proteomics
  Cancer
  SARS Coronavirus
  PKU Therapeutics
  PPI: Understanding and Modulating Protein-Protein Interaction
  New Technologies in Structural Biology
  JCIMPT: JCSG Center for Innovative Membrane Protein Technologies
  C-ME: Collaborative Molecular Modeling Environment
  Stevens Lab
  Scripps-PARC Institute for Advanced Biomedical Sciences
  Kuhn Lab Portal
  Gene Composer TM Software Downloads